Recombinant IAV NA Protein, His-tagged

• Cat.No.: NA-10I
• Product Overview: Recombinant IAV (A/Puerto Rico/8/1934(H1N1) NA Protein with 6xHis tag was purified from 293 cell culture.

Specification

• Species: IAV
• Source: HEK293
• Tag: His
• Description: Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
• Form: Purified Protein
• Purity: ≥80%
• Applications: WB standard, antibody ELISA, Functional analysis, etc
• Notes: For research use only, not for use in diagnostic procedures
• Storage: Keep it at 4 centigrade if used within a month. For long term storage, split it into small aliquots and keep at -80 centigrade. Avoid repeated freezing and thawing. The product will be expired one year after receiving if stored properly. Non-hazardous. No MSDS required.
• Storage Buffer: Each vial contains 100 μg of purified protein (1 mg/ml) in PBS.

Gene Information

• Gene Name: NA neuraminidase [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]
• Official Symbol: NA
• Synonyms: NA; neuraminidase; pentraxin-related protein PTX3; TNF alpha-induced protein 5; long pentraxin 3; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14
• Gene ID: 956530
• Protein Refseq: NP_040981
• UniProt ID: P03468