Recombinant Human WLS, His-tagged

• Cat.No.: WLS-7571H
• Product Overview: Recombinant human WLS protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Antigen Description: WLS, a Wnt trafficking regulator, is a multipass transmembrane protein that regulates the sorting and secretion of Wnt protein. It is required for organogenesis during embryogenesis and for the establishment of the anterior-posterior axis. WLS promotes various cancers such as glioma tumourigenesis. The gene encoding WLS maps to human chromosome 1 and is expressed as multiple alternatively spliced isoforms.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 17.8 kDa (155aa)
• Protein length: 101-232aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMEMSPWF QFMLFILQLD IAFKLNNQIR ENAEVSMDVS LAYRDDAFAE WTEMAHERVP RKLKCTFTSP KTPEHEGRYY ECDVLPFMEI GSVAHKFYLL NIRLPVNEKK KINVGIGEIK DIRLVGIHQN GGFTK
• Purity: >90% as determined by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: WLS wntless homolog (Drosophila) [ Homo sapiens ]
• Official Symbol: WLS
• Synonyms: WLS; EVI; MRP; GPR177; C1orf139; protein wntless homolog; G protein-coupled receptor 177; integral membrane protein GPR177; protein evenness interrupted homolog; putative NFkB activating protein 373; putative NF-kappa-B-activating protein 373; wntless homolog (Drosophila)
• Gene ID: 79971
• mRNA Refseq: NM_001002292
• Protein Refseq: NP_001002292
• MIM: 611514
• UniProt ID: Q5T9L3
• Chromosome Location: 1p31.3
• Function: Wnt-protein binding; protein binding; signal transducer activity