Recombinant Human VCPIP1 Protein (M1-S1222), His tagged

• Cat.No.: VCPIP1-0365H
• Product Overview: Recombinant Human VCPIP1(M1-S1222 end)-TEV-8His Protein was expressed in Insect cell.

Specification

• Description: Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: M1-S1222
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: VCPIP1 valosin containing protein interacting protein 1 [ Homo sapiens (human) ]
• Official Symbol: VCPIP1
• Synonyms: VCPIP1; valosin containing protein interacting protein 1; DUBA3; VCIP135; deubiquitinating protein VCPIP1; VCP/p47 complex-interacting 135-kDa protein; deubiquitinating protein VCIP135; valosin-containing protein p97/p47 complex-interacting protein 1; valosin-containing protein p97/p47 complex-interacting protein p135; EC 3.4.19.12
• Gene ID: 80124
• mRNA Refseq: NM_025054
• Protein Refseq: NP_079330
• MIM: 611745
• UniProt ID: Q96JH7