Recombinant Human UROS, His-tagged

• Cat.No.: UROS-31079TH
• Product Overview: Recombinant full length Human UROS with an N terminal His tag; 285 amino acids with a predicted MWt 30.7kDa.

Specification

• Description: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunthers disease).
• Protein length: 265 amino acids
• Conjugation: HIS
• Molecular Weight: 30.700kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitous.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC
• Sequence Similarities: Belongs to the uroporphyrinogen-III synthase family.

Gene Information

• Gene Name: UROS uroporphyrinogen III synthase [ Homo sapiens ]
• Official Symbol: UROS
• Synonyms: UROS; uroporphyrinogen III synthase; uroporphyrinogen-III synthase; congenital erythropoietic porphyria
• Gene ID: 7390
• mRNA Refseq: NM_000375
• Protein Refseq: NP_000366
• MIM: 606938
• Uniprot ID: P10746
• Chromosome Location: 10q25.2-q26.3
• Pathway: Heme Biosynthesis, organism-specific biosystem; Heme biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of porphyrins, organism-specific biosystem
• Function: cofactor binding; lyase activity; uroporphyrinogen-III synthase activity; uroporphyrinogen-III synthase activity