Recombinant Human Unc-51-Like Kinase 1 (C. elegans), GST-tagged, Active
Cat.No. : | ULK1-255H |
Product Overview : | Recombinant human ULK1 (1-649) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW = 125 kDa. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
Protein Length : | 1-649 a.a. |
Description : | ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner. |
Sequence : | 1-649. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name | ULK1 unc-51-like kinase 1 (C. elegans) [ Homo sapiens ] |
Synonyms | unc-51-like kinase 1 (C. elegans); ATG1; UNC51; Unc51.1; FLJ38455; FLJ46475; ULK1; Unc-51-like kinase 1; ATG1 autophagy related 1 homolog; EC 2.7.11.1; KIAA0722; unc-51 (C. elegans)-like kinase 1 |
Gene ID | 8408 |
mRNA Refseq | NM_003565 |
Protein Refseq | NP_003556 |
MIM | 603168 |
UniProt ID | O75385 |
Chromosome Location | 12q24.3 |
Pathway | Regulation of autophagy; mTOR signaling pathway |
Function | ATP binding; nucleotide binding; protein complex binding; protein serine/threonine kinase activity; transferase activity |
◆ Recombinant Proteins | ||
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ULK1-557H | Recombinant Human ULK1 Protein, MYC/DDK-tagged | +Inquiry |
ULK1-255H | Recombinant Human Unc-51-Like Kinase 1 (C. elegans), GST-tagged, Active | +Inquiry |
Ulk1-6830M | Recombinant Mouse Ulk1 Protein, Myc/DDK-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
ULK1-505HCL | Recombinant Human ULK1 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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