Recombinant Human UGT1A8 Protein, MYC/DDK-tagged

• Cat.No.: UGT1A8-511H
• Product Overview: Recombinant human UGT1A8 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008]
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 57.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: UDP glucuronosyltransferase family 1 member A8[ Homo sapiens ]
• Official Symbol: UGT1A8
• Synonyms: UDPGT; UDPGT 1-8; UGT-1H; UGT1-08; UGT1.8; UGT1A8S; UGT1H
• Gene ID: 54576
• mRNA Refseq: NM_019076.4
• Protein Refseq: NP_061949.3
• MIM: 606433
• UniProt ID: Q5DSZ6