Recombinant Human UGDH, His-tagged

• Cat.No.: UGDH-30103TH
• Product Overview: Recombinant full length Human UDP glucose dehydrogenase with an N terminal His tag, ; predicted mwt: ~59.5 kDa

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 494 amino acids
• Description: The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
• Conjugation: HIS
• Molecular Weight: 59.500kDa inclusive of tags
• Tissue specificity: Widely expressed.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.1M Sodium fluoride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSELEMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDPPNKKPKV
• Sequence Similarities: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Gene Information

• Gene Name: UGDH UDP-glucose 6-dehydrogenase [ Homo sapiens ]
• Official Symbol: UGDH
• Synonyms: UGDH; UDP-glucose 6-dehydrogenase; UDP glucose dehydrogenase
• Gene ID: 7358
• mRNA Refseq: NM_001184701
• Protein Refseq: NP_001171630
• MIM: 603370
• Uniprot ID: O60701
• Chromosome Location: 4p14
• Pathway: Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Ascorbate biosynthesis, animals, glucose-1P =>
• Function: NAD binding; UDP-glucose 6-dehydrogenase activity; electron carrier activity; oxidoreductase activity