Recombinant Human UFD1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: UFD1-2345H
• Product Overview: UFD1L MS Standard C13 and N15-labeled recombinant protein (NP_001030324) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 33.32 kDa
• AA Sequence: MFSFNMFDHPIPRVFQNRFSTQYRCFSVSMLAGPNDRSDVEKGGKSRLNITYPMLFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDITNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYKEPERQVQHEESTEGEADHSGYAGELGFRAFSGSGNRLDGKKKGVEPSPSPIKPGDIKRGIPNYEFKLGKITFIRNSRPLVKKVEEDEAGGRFVAFSGEGQSLRKKGRKPTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: UFD1 ubiquitin recognition factor in ER associated degradation 1 [ Homo sapiens (human) ]
• Official Symbol: UFD1
• Synonyms: UFD1; ubiquitin recognition factor in ER associated degradation 1; UFD1L; ubiquitin recognition factor in ER-associated degradation protein 1; UB fusion protein 1; ubiquitin fusion degradation 1 like; ubiquitin fusion degradation protein 1 homolog
• Gene ID: 7353
• mRNA Refseq: NM_001035247
• Protein Refseq: NP_001030324
• MIM: 601754
• UniProt ID: Q92890