Recombinant Human Ubiquitin-Conjugating Enzyme E2L6, His-tagged

• Cat.No.: UBE2L6-30H
• Product Overview: Recombinant human UBE2L6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 21.7kDa (188aa).

Specification

• Cat. No.: UBE2L6-30H
• Description: Ubiquitin-conjugating enzyme E2L6 (UBE2L6), also known as UbcH8, is a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination of a protein substrate requires the concerted action of 3 classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases. The E2 ubiquitin-conjugating enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene.
• Source: Escherichia Coli.
• Form: Liquid in 20mM Tris pH 8.0, 1 mM DTT, 0.1 mM PMSF 10% glycerol.
• Purity: > 90% by SDS PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASM RVVKE LEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFP PEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALN VLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: UBE2L6 ubiquitin-conjugating enzyme E2L 6 [ Homo sapiens ]
• Synonyms: ubiquitin-conjugating enzyme E2L 6; RIG-B; UBCH8; MGC40331; UBE2L6; ubiquitin-protein ligase; ubiquitin carrier protein; retinoic acid induced gene B protein; EC 6.3.2.19; MGC40331; Retinoic acid-induced gene B protein; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6; ubiquitin-protein ligase.
• Gene ID: 9246
• mRNA Refseq: NM_004223
• Protein Refseq: NP_004214
• MIM: 603890
• UniProt ID: O14933
• Chromosome Location: 11q12
• Function: ligase activity; protein binding; ubiquitin-protein ligase activity