Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein II, His-tagged

• Cat.No.: UQCRC2-7158H
• Product Overview: Recombinant human UQCRC2 protein, fused to His-tag at N-terminus, was expressed in E. coli. MW: 49 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 15-453aa
• Description: Cytochrome b-c1 complex subunit 2, mitochondrial, also known as UQCRC2, belongs to the peptidase M16 family. This protein is a component of the ubiquinol-cytochrome c reductase complex (complex III), which is part of the mitochondrial respiratory chain. UQCRC2 is required for the assembly of the complex.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M Urea, 10% glycerol, 0.1M NaCl.
• Molecular Mass: 49 kDa (460aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MSLKVAPKVK ATAAPAGAPP QPQDLEFTKL PNGLVIASLE NYSPVSRIGL FIKAGSRYED FSNLGTTHLL RLTSSLTTKG ASSFKITRGI EAVGGKLSVT ATRENMAYTV ECLRGDVDIL MEFLLNVTTA PEFRRWEVAD LQPQLKIDKA VAFQNPQTHV IENLHAAAYR NALANPLYCP DYRIGKVTSE ELHYFVQNHF TSARMALIGL GVSHPVLKQV AEQFLNMRGG LGLSGAKANY RGGEIREQNG DSLVHAAFVA ESAVAGSAEA NAFSVLQHVL GAGPHVKRGS NTTSHLHQAV AKATQQPFDV SAFNASYSDS GLFGIYTISQ ATAAGDVIKA AYNQVKTIAQ GNLSNTDVQA AKNKLKAGYL MSVESSECFL EEVGSQALVA GSYMPPSTVL QQIDSVANAD IINAAKKFVS GQKSMAASGN LGHTPFVDEL
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: UQCRC2 ubiquinol-cytochrome c reductase core protein II [ Homo sapiens ]
• Official Symbol: UQCRC2
• Synonyms: UQCRC2; ubiquinol-cytochrome c reductase core protein II; cytochrome b-c1 complex subunit 2, mitochondrial; QCR2; UQCR2; core protein II; complex III subunit 2; ubiquinol-cytochrome-c reductase complex core protein 2
• Gene ID: 7385
• mRNA Refseq: NM_003366
• Protein Refseq: NP_003357
• MIM: 191329
• UniProt ID: P22695
• Chromosome Location: 16p12
• Pathway: Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Cytochrome bc1 complex, organism-specific biosystem; Cytochrome bc1 complex, conserved biosystem; Electron Transport Chain, organism-specific biosystem
• Function: catalytic activity; metal ion binding; metalloendopeptidase activity; protein complex binding; zinc ion binding