Recombinant Human UBE2N, His-tagged
Cat.No. : | UBE2N-238H |
Product Overview : | Recombinant human UBE2N (UBC13) (2-end) was expressed in E. coli cells using an N-terminal His tag. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 2-end a.a. |
Description : | UBE2N (UBC13) or ubiquitin-conjugating enzyme E2N is a member of the E2 ubiquitin-conjugating enzyme family which plays a role in DNA post-replication repair. UBE2N gene encodes a novel human E2 that may be involved in protein degradation in the muscles and testis. UBE2N plays a role in initiation of homologous recombination during double-strand break repair. UBE2N activity may have therapeutic uses in controlling inflammatory responses and it is also important in the induction of immune responses. |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~18 kDa |
Purity : | >95% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name | UBE2N ubiquitin-conjugating enzyme E2N [ Homo sapiens ] |
Official Symbol | UBE2N |
Synonyms | UBE2N; ubiquitin-conjugating enzyme E2N; ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) , ubiquitin conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-conjugating enzyme E2 N; MGC8489; UBC13; UbcH ben; yeast UBC13 homolog; ubiquitin-protein ligase N; ubiquitin carrier protein N; bendless-like ubiquitin conjugating enzyme; bendless-like ubiquitin-conjugating enzyme; ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); UbcH-ben; MGC131857; |
Gene ID | 7334 |
mRNA Refseq | NM_003348 |
Protein Refseq | NP_003339 |
MIM | 603679 |
UniProt ID | P61088 |
Chromosome Location | 12q22 |
Pathway | Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; |
Function | ATP binding; acid-amino acid ligase activity; ligase activity; nucleotide binding; protein binding; ubiquitin binding; ubiquitin-protein ligase activity; |
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Not For Human Consumption!
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