Recombinant Human Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1, Fc-tagged

• Cat.No.: TIE1-1913H
• Product Overview: Recombinant humansoluble TIE1 was fused with the Fc part of human IgG1.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Fc
• Description: TIE1 and TIE2 comprisea receptor tyrosine kinase subfamily with unique structural characteristics:two immunoglobulin-like domains flanking three epidermal growth factor-likedomains and followed by three fibronectin type III-like repeats in theextracellular region and a split tyrosine kinase domain in the cytoplasmicregion.
• Form: Lyophilized
• Purity: > 90% by SDS-PAGEand visualized by silver stain.
• Molecular Weight: 250 kDa
• Subunit: Glycosylated dimer
• Endotoxin Level: < 0.1 ng per μgof sTIE-1/Fc.
• Biological Activity: Since a ligand forTIE1 has not yet been identified, the recombinant protein was not tested forbiological activity.
• Storage: Samples are stablefor 2-4 weeks at +4°C. sTIE-1/Fc should be stored in working aliquots at-20°C to -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: TIE1

Gene Information

• Gene Name: TIE1 tyrosine kinase withimmunoglobulin-like and EGF-like domains 1 [ Homo sapiens ]
• Synonyms: TIE1; tyrosinekinase with immunoglobulin-like and EGF-like domains 1; TIE; JTK14; tyrosine-proteinkinase receptor Tie-1; OTTHUMP00000008352; soluble TIE1 variant 1; solubleTIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1variant 5; receptor tyrosine kinase; tyrosine kinase with immunoglobulin andepidermal growth factor homology domains 1; EC 2.7.10.1; Tyrosine-protein kinase receptor Tie-1
• Gene ID: 7075
• mRNA Refseq: NM_005424
• Protein Refseq: NP_005415
• MIM: 600222
• UniProt ID: P35590
• Chromosome Location: 1p34-p33
• Function: ATP binding;nucleotide binding; protein binding; protein tyrosine kinase activity;receptor activity; transmembrane receptor protein tyrosine kinase activity