Recombinant Human TXNDC12, His-tagged

• Cat.No.: TXNDC12-3498H
• Product Overview: Recombinant Human TXNDC12(His 27 - Leu 172), fused with 6×His tag at the C-terminus, was expressed in human 293 cells.

Specification

• Description: This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
• Molecular Mass: rhTXNDC12, fused with 6×His tag at the C-terminus, has a calculated MW of 17.3 kDa. The predicted N-terminus is His 27. DTT-reduced Protein migrates as 18-21 kDa.
• Endotoxin: Less than 1.0 EU per μg of the rhTXNDC12 by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
• Protein length: 27-172 a.a.

Gene Information

• Gene Name: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) [ Homo sapiens (human) ]
• Official Symbol: TXNDC12
• Synonyms: TXNDC12; thioredoxin domain containing 12 (endoplasmic reticulum); thioredoxin domain-containing protein 12; AGR1; anterior gradient homolog 1 (Xenopus laevis); endoplasmic reticulum thioredoxin superfamily member; 18 kDa; ERP18; ERP19; hAG 1; PDIA16; protein disulfide isomerase family A; member 16; TLP19; ER protein 18; ER protein 19; anterior gradient homolog 1; thioredoxin-like protein p19; endoplasmic reticulum protein ERp19; endoplasmic reticulum resident protein 18; endoplasmic reticulum resident protein 19; protein disulfide isomerase family A, member 16; endoplasmic reticulum thioredoxin superfamily member, 18 kDa; AG1; ERP16; hAG-1; hTLP19
• Gene ID: 51060
• mRNA Refseq: NM_015913
• Protein Refseq: NP_056997
• MIM: 609448
• UniProt ID: O95881
• Chromosome Location: 1p32.3
• Pathway: Glutathione metabolism
• Function: protein binding; protein-disulfide reductase (glutathione) activity