Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 14

• Cat.No.: TNFSF14-354H
• Product Overview: Recombinant human TNFSF14was expressed in E. coli and purified recombinant Human TNFSF14 protein.

Specification

• Cat. No.: TNFSF14-354H
• Description: TNFSF14 belongs tothe TNF family of ligands, and can signal through the herpes virus entrymediator type A receptor (HVEM, TNFRSF14), LTbetaR, or bind to a decoyreceptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8tumor infiltrating lymphocytes, granulocytes, and monocytes. TNFSF14 has theability to active NF kb, to co-stimulate the activation of lymphocytes and toinduce apoptosis in certain human tumor cells.
• Source: Human
• Host: E. coli
• Form: Supplied as alyophilized powder.
• Purity: > 98% pure by SDSPAGE and HPLC
• Sequence: 1-248 amino acids:MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSNEEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDKKRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSEDSYKD
• Molecular Mass: 20.1 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: TNFSF14
• Tag: Non

Gene Information

• Gene Name: TNFSF14tumor necrosis factor (ligand) superfamily, member 14 [ Homo sapiens ]
• Synonyms: TNFSF14; tumor necrosis factor(ligand) superfamily, member 14; LTg; TR2; CD258; HVEML; LIGHT; deltatransmembrane LIGHT; herpesvirus entry mediator A; ligand for herpesvirusentry mediator; tumor necrosis factor receptor-like 2; tumor necrosis factorsuperfamily member LIGHT; CD258 antigen; Herpesvirus entry mediator-ligand;ligand for herpesvirus entry mediator; tumor necrosis factor ligandsuperfamily, member 14; HVEM-L; Tumor necrosis factor ligand superfamilymember 14, membrane form; Tumor necrosis factor ligand superfamily member 14,soluble form
• Gene ID: 8740
• mRNA Refseq: NM_003807
• Protein Refseq: NP_003798
• MIM: 604520
• UniProt ID: O43557
• Chromosome Location: 19p13.3
• Pathway: Cytokine-cytokine receptorinteraction; Herpessimplex infection
• Function: caspase inhibitor activity;cytokine activity; tumor necrosis factor receptor binding