Recombinant Human Transforming Growth Factor, Beta 1, GST-tagged

• Cat.No.: TGFB1-119H
• Product Overview: Recombinant Human TGF-b 1 (177-391 a.a.) produced inE.coliis purified by standard chromatographic techniques and shows a 51 kDa band on SDS-PAGE (including GST tag).

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
• Physical Appearance: Sterile Filtered solution at a concentration of 0.1 mg/ml.
• Purity: Greater than 80.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: The protein solution contains 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
• Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Leu-Asp-Thr-Asn.
• Storage: TGF-beta 1 although stable at 4°C for 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Gene Information

• Gene Name: TGFB1 transforming growth factor, beta 1 [ Homo sapiens ]
• Synonyms: TGFB1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; Transforming growth factor beta-1; TGF-beta-1; Latency-associated peptide; LAP
• Gene ID: 7040
• mRNA Refseq: NM_000660
• Protein Refseq: NP_000651
• MIM: 190180
• UniProt ID: P01137
• Chromosome Location: 19q13.1
• Pathway: Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Hemostasis; Influenza Infection; Signaling by TGF beta
• Function: growth factor activity; protein N-terminus binding; protein heterodimerization activity; protein homodimerization activity; transcription activator activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding