Recombinant Human TPT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: TPT1-4514H
• Product Overview: TPT1 MS Standard C13 and N15-labeled recombinant protein (NP_003286) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 19.6 kDa
• AA Sequence: MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKCTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: TPT1 tumor protein, translationally-controlled 1 [ Homo sapiens (human) ]
• Official Symbol: TPT1
• Synonyms: TPT1; tumor protein, translationally-controlled 1; translationally-controlled tumor protein; fortilin; TCTP; p23; histamine-releasing factor; HRF; p02; FLJ27337
• Gene ID: 7178
• mRNA Refseq: NM_003295
• Protein Refseq: NP_003286
• MIM: 600763
• UniProt ID: P13693