Recombinant Human TNNI1 protein, His-tagged

• Cat.No.: TNNI1-4836H
• Product Overview: Recombinant Human TNNI1 fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Troponin1 is a member of the tropomyosin family and regulates the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin1 is part of a complex with troponin T and troponin C in which Troponin1 acts as an inhibitory subunit that blocks actin-myosin interactions and thereby mediates striated muscle relaxation. Troponin1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The Troponin1 protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
• Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Molecular Mass: ~24 kDa
• Purity: >75%
• Applications: Western Blot
• Stability: 1year at - 70 centigrade from date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 μg/μl

Gene Information

• Gene Name: TNNI1 troponin I type 1 (skeletal, slow) [ Homo sapiens ]
• Official Symbol: TNNI1
• Synonyms: TNNI1; troponin I type 1 (skeletal, slow); troponin I, skeletal, slow; troponin I, slow skeletal muscle; troponin I, slow-twitch isoform; TNN1; SSTNI; DKFZp451O223
• Gene ID: 7135
• mRNA Refseq: NM_003281
• Protein Refseq: NP_003272
• MIM: 191042
• UniProt ID: P19237
• Chromosome Location: 1q31.3
• Pathway: Muscle contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem; Striated Muscle Contraction, organism-specific biosystem
• Function: actin binding; tropomyosin binding