Recombinant Human TNFSF18, FLAG-tagged

• Cat.No.: TNFSF18-2564H
• Product Overview: Recombinant Human TNFSF18 was expressed in a human embryonic kidney cell line,TNFSF18,and purified from condition. The DNA sequence encoding extracellular domain of human GITR ligand (amino acid 50~177) was tagged with the FLAG peptide sequence at the N-terminus.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag
• Description: Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
• Formulation: Lyophilized from 0.2 μm filtered solution in phosphate-buffered saline.
• Activity: Lbinding to human GITR transfected cells.
• Stability Storage And Handling: The Lyophilized proteins should be stored at 20℃. Centrifuge briefly before opening the vial and reconstitute the lyophilized proteins in an appropriate buffer. The solubilized proteins should be stored in working aliquots at -20℃ for a few months.
• Purity: >95%, as determined by SDS-PAGE.
• Endotoxin Level: <0.1 EU/µg, as determined by the LAL method.

Gene Information

• Gene Name: TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 [ Homo sapiens ]
• Synonyms: Osteostat; TNFSF18; Tumor necrosis factor ligand superfamily member 18; GITRL; TL6; AITRL; hGITRL; MGC138237; AITR ligand; Activation-inducible TNF-related ligand; GITR ligand; Activation-induced TNFR member Ligand; Glucocorticoid-induced TNF-related ligand; Glucocorticoid-induced TNFR-related protein ligand
• Gene ID: 8995
• mRNA Refseq: NM_005092
• Protein Refseq: NP_005083
• MIM: 603898
• UniProt ID: Q9UNG2
• Chromosome Location: 1q23
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity; tumor necrosis factor receptor binding