Recombinant Human TNFSF11, His-tagged

• Cat.No.: TNFSF11-3744H
• Product Overview: Soluble Receptor Activator of NFĸB Ligand (sRANKL) Mouse Recombinant produced in E.coli is single, non-glycosylated, polypeptide chain containing 179 amino acids and having a total molecular mass of 19.9 kDa. CD254 is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 149-317 a.a.
• Description: Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.
• Form: The protein (1 mg/ml) was lyophilized with 10mM NaP, pH 7.5 + 50 NaCl.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE
• Sequences of amino acids: PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID
• Storage: Lyophilized rec. Human sRANKL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHu sRANKL should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Pathways: Cytokine-cytokine receptor interaction; IL6-mediated signaling events; Osteoblast Signaling; Osteoclast differentiation; Rheumatoid arthritis

Gene Information

• Gene Name: TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ]
• Official Symbol: TNFSF11
• Synonyms: TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine; CD antigen; OTTHUMP00000018328; OTTHUMP00000178585; CD254 antigen
• Gene ID: 8600
• mRNA Refseq: NM_003701
• Protein Refseq: NP_003692
• MIM: 602642
• Uniprot ID: O14788
• Chromosome Location: 13q14
• Function: cytokine activity; receptor activity; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding