Recombinant Human TNFSF11
Cat.No. : | TNFSF11-31288TH |
Product Overview : | Highly pure (>98%) recombinant human sRANKL. |
- Specification
- Gene Information
- Related Products
- Download
Species : | Human |
Source : | E.coli |
Tag : | Non |
Protein Length : | 143-317 aa |
Description : | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
Tissue specificity : | Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. |
Form : | Lyophilised |
Storage buffer : | Formulized from 5mM Sodium Phosphate, pH 7.6 + 75 mM NaCl. |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | hsRANK-L is a soluble 20.0 kDa protein, comprising the full-length of the TNF-like extracellular domain of RANKL:MEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSW YHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRH HETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGST KYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSL LDPDQDATYFGAFKVRDID |
Sequence Similarities : | Belongs to the tumor necrosis factor family. |
Gene Name | TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ] |
Official Symbol | TNFSF11 |
Synonyms | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; CD254; ODF; OPGL; RANKL; TRANCE; |
Gene ID | 8600 |
mRNA Refseq | NM_003701 |
Protein Refseq | NP_003692 |
MIM | 602642 |
Uniprot ID | O14788 |
Chromosome Location | 13q14 |
Pathway | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL6-mediated signaling events, organism-specific biosystem; Osteoblast Signaling, organism-specific biosystem; Osteoclast Signaling, organism-specific biosystem; |
Function | cytokine activity; cytokine activity; receptor activity; tumor necrosis factor receptor binding; tumor necrosis factor receptor binding; |
◆ Recombinant Proteins | ||
TNFSF11-210CF | Active Recombinant Monkey TNFSF11 Protein, Fc-tagged, FITC conjugated | +Inquiry |
VEGFA-587H | Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 11, His-Fc-Tagged | +Inquiry |
Tnfsf11-6551M | Active Recombinant Mouse Tnfsf11 Protein | +Inquiry |
TNFSF11-0265H | Active Recombinant Human TNFSF11 protein, mFc-tagged | +Inquiry |
TNFSF11-252H | Active Recombinant Human TNFSF11, Met-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
TNFSF11-998HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-001CCL | Recombinant Cynomolgus TNFSF11 cell lysate | +Inquiry |
TNFSF11-1586MCL | Recombinant Mouse TNFSF11 cell lysate | +Inquiry |
TNFSF11-1093HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All TNFSF11 Products
Required fields are marked with *
My Review for All TNFSF11 Products
Required fields are marked with *
0
Inquiry Basket