Recombinant Human TNFRSF14, Fc-tagged

• Cat.No.: TNFRSF14-30480TH
• Product Overview: Recombinant human TNFRSF14-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of TNFRSF14 and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.

Specification

• Species: Human
• Tag: Fc
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.
• Conjugation: Fc
• Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus.
• Biological activity: Biological Activity : Determined by its ability to neutralize 0.25 ng/ml of hTNFbeta induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3-1.9 μg/ml of TNFRSF14.
• Form: Lyophilised
• Purity: >95% by SDS-PAGE
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 3 TNFR-Cys repeats.

Gene Information

• Gene Name: TNFRSF14 tumor necrosis factor receptor superfamily, member 14 [ Homo sapiens ]
• Official Symbol: TNFRSF14
• Synonyms: TNFRSF14; tumor necrosis factor receptor superfamily, member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); tumor necrosis factor receptor superfamily member 14; ATAR; CD270; herpesvirus entry mediator; HVEA; HVEM
• Gene ID: 8764
• mRNA Refseq: NM_003820
• Protein Refseq: NP_003811
• MIM: 602746
• Uniprot ID: Q92956
• Chromosome Location: 1p36.32
• Pathway: Adaptive Immune System, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Herpes simplex infection, organism-specific biosystem
• Function: protein binding; receptor activity; tumor necrosis factor-activated receptor activity