Recombinant Human TNFRSF10D

• Cat.No.: TNFRSF10D-1693H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.
• Molecular Weight: The predicted molecular weight of Recombinant Human TRAIL R4 is Mr 44.2 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain [ Homo sapiens ]
• Synonyms: TNFRSF10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain; DCR2; CD264; TRUNDD; TRAILR4; tumor necrosis factor receptor superfamily, member 10d; TRAIL receptor 4; decoy receptor 2; decoy with truncated death domain; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; DcR2; TRAIL-R4; CD264 antigen; TNF-related apoptosis-inducing ligand receptor 4
• Gene ID: 8793
• mRNA Refseq: NM_003840
• Protein Refseq: NP_003831
• MIM: 603614
• UniProt ID: Q9UBN6
• Chromosome Location: 8p21
• Pathway: Apoptosis; Cytokine-cytokine receptor interaction; Natural killer cell mediated cytotoxicity
• Function: protein binding; transmembrane receptor activity