Recombinant Human TMED4, Fc-tagged

• Cat.No.: TMED4-181H
• Product Overview: Recombinant Human TMED4 /ERS25 Protein,With C-Fc Tag (rh TMED4 / ERS25 Fc Chimera) Leu 30 - Arg 194 (Accession # AAH57851) was produced in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• ProteinLength: 30-194 a.a.
• Description: Transmembrane emp24 domain-containing protein 4 ( TMED4) is also known as Endoplasmic reticulum stress-response protein 25 (ERS25), GMP25iso, p24 family protein alpha-3 (p24alpha3), which belongs to the EMP24/GP25L family. TMED4 is involved in vesicular protein trafficking, mainly in the early secretory pathway. TMED4 appears to play a role in the biosynthesis of secreted cargo including processing. TMED4 is also involved in endoplasmic reticulum stress response, and may play a role in the regulation of heat-shock response and apoptosis.
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
• Molecular Mass: rh TMED4 / ERS25 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 45.9 kDa. The predicted N-terminus is Leu 30. DTT-reduced Protein migrates as 48 kDa in SDS-PAGE due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg of the rh TMED4 / ERS25 Fc Chimera by the LAL method.
• Purity: >92% as determined by SDS-PAGE.
• Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
• Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.

Gene Information

• Gene Name: TMED4 transmembrane emp24 protein transport domain containing 4 [ Homo sapiens ]
• Official Symbol: TMED4
• Synonyms: TMED4; transmembrane emp24 protein transport domain containing 4; transmembrane emp24 domain-containing protein 4; HNLF; GMP25iso; p24alpha3; p24 family protein alpha-3; putative NFkB activating protein HNLF; putative NF-kappa-B-activating protein 156; endoplasmic reticulum stress-response protein 25 kDa; ERS25
• Gene ID: 222068
• mRNA Refseq: NM_182547
• Protein Refseq: NP_872353
• MIM: 612038
• UniProt ID: Q7Z7H5
• Chromosome Location: 7p13
• Function: signal transducer activity