Recombinant Human Thyrotropin Hormone Protein, His tagged

• Cat.No.: TSH-16H
• Product Overview: Human Thyrotropin hormone, or thyroid-stimulating hormone (TSH), produced in HEK293 cells and purified by affinity chromatography and dialysis.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: Thyrotropin, or thyroid-stimulating hormone (TSH), is a glycoprotein hormone secreted by the anterior pituitary that plays a central role in regulating the endocrine function of the thyroid gland. Structurally, TSH consists of two subunits—alpha and beta—where the alpha subunit is common to other glycoprotein hormones (e.g., LH, FSH), and the beta subunit confers hormonal specificity by binding to TSH receptors on thyroid follicular cells. Upon binding, TSH stimulates the synthesis and release of thyroid hormones (T3 and T4), which in turn regulate metabolism, growth, and development. Clinically, serum TSH measurement is a cornerstone in the assessment of thyroid function, often used alongside free T4 and T3 assays for diagnosing hypo- or hyperthyroidism. Traditional TSH assays, however, have faced challenges such as cross-reactivity and glycosylation variability. To improve accuracy and standardization, recombinant human TSH has been developed and widely adopted in both diagnostic stimulation tests and thyroid cancer follow-up, offering enhanced assay consistency and safety. Recombinant TSH also eliminates the need for thyroid hormone withdrawal during testing, significantly improving patient quality of life and enabling more sensitive and specific diagnostic procedures.
• Form: Liquid in DPBS.
• Molecular Mass: Expected Molecular Weight: 17.6 / 15.6 kDa Observed Molecular Weight: 28 /18 kDa
• Storage: Short Term Storage: -80 centigrade Long Term Storage: -80 centigrade Avoid multiple freeze-thaw cycles. Can be frozen, but avoid multiple freeze-thaw cycles.
• Concentration: 0.18 mg/mL
• Reference: 1. Szkudlinski, M. W., et al. (2002). Thyroid-stimulating hormone and TSH receptor structure-function relationships. Physiological Reviews, 82(2), 473–502. 2. Pirahanchi Y, Toro F, Jialal I. Physiology, Thyroid Stimulating Hormone. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan, 3. Pacini F, Castagna MG. Diagnostic and therapeutic use of recombinant human TSH (rhTSH) in differentiated thyroid cancer. Best Pract Res Clin Endocrinol Metab. 2008 Dec;22(6):1009-21.

Gene Information

• Gene Name: CGA glycoprotein hormones, alpha polypeptide [ Homo sapiens ]
• Official Symbol: CGA
• Synonyms: CGA; glycoprotein hormones, alpha polypeptide; glycoprotein hormones alpha chain; chorionic gonadotropin; alpha polypeptide; follicle stimulating hormone alpha subunit; FSHA; GPHa; GPHA1; HCG; LHA; luteinizing hormone alpha chain; lutropin alpha chain; thyroid stimulating hormone alpha chain; TSHA; FSH-alpha; LSH-alpha; TSH-alpha; follitropin alpha chain; thyrotropin alpha chain; choriogonadotropin alpha chain; chorionic gonadotrophin subunit alpha; thyroid-stimulating hormone alpha chain; follicle-stimulating hormone alpha chain; chorionic gonadotropin, alpha polypeptide; follicle-stimulating hormone alpha subunit; anterior pituitary glycoprotein hormones common subunit alpha; CG-ALPHA
• Gene ID: 1081
• mRNA Refseq: NM_000735
• Protein Refseq: NP_000726
• MIM: 118850
• UniProt ID: P01215
• Gene Name 2: TSHB thyroid stimulating hormone, beta [ Homo sapiens ]
• Official Symbol 2: TSHB
• Synonyms 2: TSHB; thyroid stimulating hormone, beta; thyrotropin subunit beta; thyrotropin beta chain; thyrotropin beta subunit; thyroid-stimulating hormone subunit beta; TSH-B; TSH-BETA
• Gene ID 2: 7252
• mRNA Refseq 2: NM_000549
• Protein Refseq 2: NP_000540
• MIM 2: 188540
• UniProt ID 2: P01222