Recombinant Human Thioredoxin-like 4A, His-tagged

• Cat.No.: TXNL4A-6772H
• Product Overview: . Recombinant humanTXNL4A protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Thioredoxin-like 4A,also known as TXNL4A, belongs to the Dim protein family. TXNL4A is a 142amino acid protein that plays an essential role in pre-mRNA splicing. Due toa failure to express early zygotic transcripts, deletion of the gene encodingTXNL4A in Schizosaccharomyces pombe leads to embryonal lethality duringgastrulation. Localized to the nucleus, TXNL4A interacts with hnRNP F, hnRNPH2, Cas-L and PQBP-1 to effect gene expression
• Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol, 1mM DTT
• Molecular Weight: 19.3 kDa (166aa),confirmed by MALDI-TOF
• Purity: > 95% by SDS -PAGE
• Concentration: 0.5 mg/ml(determined by Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMSYMLP HLHNGWQVDQ AILSEEDRVV VIRFGHDWDP TCMKMDEVLY SIAEKVKNFAVIYLVDITEV PDFNKMYELY DPCTVMFFFR NKHIMIDLGT GNNNKINWAM EDKQEMVDII ETVYRGARKGRGLVVSPKDY STKYRY
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: TXNL4A thioredoxin-like 4A [Homosapiens]
• Official symbol: TXNL4A
• Synonyms: thioredoxin-like4A; Spliceosomal U5 snRNP-specific 15 kDa protein; DIM1; Thioredoxin-like U5snRNP protein U5-15kD; DIB1; TXNL4; HsT161; DIM1 protein homolog; U5-15kD;thioredoxin-like protein 4A; thioredoxin-like 4
• Gene ID: 10907
• mRNA Refseq: NM_006701
• Protein Refseq: NP_006692
• MIM: 611595
• Uniprot ID: P83876
• Chromosome Location: 18q23
• Pathway: Formationand Maturation of mRNA Transcript, organism-specific biosystem; GeneExpression, organism-specific biosystem; Processing of CappedIntron-Containing Pre-mRNA, organism-specific biosystem; Spliceosome,organism-specific biosystem; Spliceosome, conserved biosystem; mRNAProcessing, organism-specific biosystem
• Function: protein binding