Recombinant Human TGIF1

• Cat.No.: TGIF1-31143TH
• Product Overview: Recombinant full lenght human TGIF protein isoform 2, 31 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: TGIF1 TGFB-induced factor homeobox 1 [ Homo sapiens ]
• Official Symbol: TGIF1
• Synonyms: TGIF1; TGFB-induced factor homeobox 1; HPE4, TGFB induced factor (TALE family homeobox) , TGIF; homeobox protein TGIF1
• Gene ID: 7050
• mRNA Refseq: NM_003244
• Protein Refseq: NP_003235
• MIM: 602630
• Uniprot ID: Q15583
• Chromosome Location: 18p11.31
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Id Signaling Pathway, organism-specific biosystem; Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
• Function: chromatin binding; co-SMAD binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity