Recombinant Human TGFBR1, GST-His

• Cat.No.: TGFBR1-716H
• Product Overview: Recombinant Human TGFB-R1, C-terminal fragment, amino acids T200-M503, N-terminal GST-HIS6 fusion protein with a Thrombin cleavage site, was expressed inSf9insect cells.MW = 64,168 Da.

Specification

• Cat. No.: TGFBR1-716H
• Description: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
• Source: Baculovirus infected Sf9 cells.
• Purification: GST-Affinity Chromatography.
• Product Identity: TGFB-R1 was confirmed as TGFB-R1 by mass spectroscopy LCESI-MS/MS.
• Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol.
• Concentration: 0.193 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
• Specific Activity: 501 pmol/μg×min.
• Storage: -80°C. Avoid repeated freeze-thaw cycles!

Gene Information

• Gene Name: TGFBR1 transforming growth factor, beta receptor 1 [ Homo sapiens ]
• Synonyms: TGFBR1; transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; 9q22; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53Kd; activin A receptor type II-like kinase, 53kDa; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); EC 2.7.11.30; TGF-beta receptor type-1; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TGF-beta type I receptor; TbetaR-I; OTTHUMP00000021783
• Gene ID: 7046
• mRNA Refseq: NM_001130916
• Protein Refseq: NP_001124388
• MIM: 190181
• UniProt ID: P36897
• Chromosome Location: 9q22
• Pathway: Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein complex binding; protein heterodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; type II transforming growth factor beta receptor binding; ubiquitin protein ligase binding