Recombinant Human SUMO1 protein, His-tagged

• Cat.No.: SUMO1-7040H
• Product Overview: Recombinant Human SUMO1 (Met1-Val101) protein was fused to His-tag at N-terminus and expressed in E.coli.

Specification

• Description: Small ubiquitin-related modifier 1 (SUMO1),a member of the ubiquitin family and SUMO subfamily, is also known as GAP-modifying protein 1 (GMP1), SMT3 homolog 3, ubiquitin-homology domain protein PIC1 and ubiquitin-like protein UBL1,which contains one ubiquitin-like domain. Cleavage of precursor form by SENP1 or SENP2 is necessary for the function of SUMO1. Polymeric SUMO1 chains undergo polyubiquitination by RNF4. SUMO1 may also regulate a network of genes involved in palate development.SUMO1 plays an important role in modulation of NOX activity required for ROS generation.
• Source: E.coli
• Species: Human
• Tag: His
• Predicted N Terminal: Met1
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 12.4 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).
• Protein length: Met1-Val101
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: SUMO1
• Official Symbol: SUMO1
• Synonyms: SUMO1; SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 1 (yeast), ubiquitin like 1 (sentrin), UBL1; small ubiquitin-related modifier 1; GMP1; OFC10; PIC1; SMT3C; SMT3H3; SUMO 1; sentrin; SMT3 homolog 3; GAP modifying protein 1; ubiquitin-like protein UBL1; ubiquitin-like protein SMT3C; ubiquitin-homology domain protein PIC1; DAP1; SMT3; UBL1; SENP2
• Gene ID: 7341
• mRNA Refseq: NM_001005781
• Protein Refseq: NP_001005781
• MIM: 601912
• UniProt ID: P63165

Reviews

05/07/2022

Swift protein expression optimization, boosts our research efficiency.

11/30/2021

Accurate protein structural characterization, vital for our studies.

02/03/2018

High-quality protein sequencing, invaluable for our work.

Q&As

How do alterations in SUMO1 expression or conjugation affect cancer development and progression?

Changes in SUMO1 expression or activity can contribute to cancer development, affecting tumor cell behavior and environment.

How does SUMO1 modification affect the stability and function of target proteins?

SUMO1 modification alters target protein stability and function, affecting various cellular processes.

What role does SUMO1 play in regulating gene expression and chromatin organization?

SUMO1 regulates gene expression and chromatin structure, influencing transcriptional activity.

How does SUMO1 influence the DNA damage response and repair processes?

SUMO1 is involved in the DNA damage response, aiding in DNA repair and maintaining genomic integrity.

What is the impact of SUMO1 on cellular stress responses, particularly in neurodegenerative diseases?

SUMO1 impacts cellular stress responses, playing a significant role in neurodegenerative disease mechanisms.

How does SUMO1 contribute to the regulation of cell cycle progression and apoptosis?

SUMO1 modulates cell cycle progression and apoptosis, contributing to cell survival and turnover.

What are the mechanisms by which SUMO1 modulates signal transduction pathways, especially in immune responses?

SUMO1 influences signal transduction, particularly in immune cell signaling and response.