Recombinant Human Sulfatase Modifying Factor 1, His-tagged

Cat. No. :	SUMF1-1539H
Description :	SUMF1 (Sulfatase-modifying factor 1) belongs to the SUMF family. SUMF1 is an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder.
Form :	Liquid. In 20mM Tris-HCl, pH8.0, 2M Urea, 20%Glycerol, 2mM DTT
Molecular Weight :	34.1kDa (304aa)
Purity :	> 85% by SDS - PAGE
Concentration :	0.5mg/ml (determined by Bradford assay)
Sequences of amino acids :	MGSSHHHHHH SSGLVPRGSH MVPIPAGVFT MGTDDPQIKQ DGEAPARRVT IDAFYMDAYE VSNTEFEKFV NSTGYLTEAE KFGDSFVFEG MLSEQVKTNI QQAVAAAPWW LPVKGANWRH PEGPDSTILH RPDHPVLHVS WNDAVAYCTW AGKRLPTEAE WEYSCRGGLH NRLFPWGNKL QPKGQHYANI WQGEFPVTNT GEDGFQGTAP VDAFPPNGYG LYNIVGNAWE WTSDWWTVHH SVEETLNPKG PPSGKDRVKK GGSYMCHRSY CYRYRCAARS QNTPDSSASN LGFRCAADRL PTMD
Storage :	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways :	Lysosome

Gene Name	SUMF1 sulfatase modifying factor 1 [ Homo sapiens ]
Official Symbol	SUMF1
Synonyms	SUMF1; FGE; UNQ3037; AAPA3037; MGC131853; MGC150436; sulfatase-modifying factor 1; OTTHUMP00000115300; OTTHUMP00000207086; OTTHUMP00000207089; FGly-generating enzyme; C-alpha-formylglycine-generating enzyme 1; sulfatase modifying factor 1; OTTHUMP00000207088; EC 1.8.99
Gene ID	285362
mRNA Refseq	NM_182760
Protein Refseq	NP_877437
MIM	607939
UniProt ID	Q8NBK3
Chromosome Location	3p26.1
Function	binding; metal ion binding; oxidoreductase activity; protein homodimerization activity