Recombinant Human STAT5A, His-tagged

• Cat.No.: STAT5A-1498H
• Product Overview: Recombinant full-length human STAT5 was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 92 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: STAT5 (signal transducers and activators of transcription 5) is a member of the STAT family and this protein is phosphorylated by receptor associated protein kinases in response to cytokines and growth factors. The differentiation of T helper (Th) cells is regulated by members of the STAT family of signaling molecules. In BCR-ABL-positive cells, STAT5 is constitutively activated by tyrosine phosphorylation. STAT5 activation results in upregulation of Bcl-XL and increased resistance to induction of apoptosis. STAT5 is involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: STAT5A signal transducer and activator of transcription 5A [ Homo sapiens ]
• Synonyms: STAT5A; signal transducer and activator of transcription 5A; MGF; STAT5; STAT5
• Gene ID: 6776
• mRNA Refseq: NM_003152
• Protein Refseq: NP_003143
• MIM: 601511
• UniProt ID: P42229
• Chromosome Location: 17q11.2
• Pathway: Acute myeloid leukemia; Chronic myeloid leukemia; ErbB signaling pathway; Jak-STAT signaling pathway; Pathways in cancer
• Function: calcium ion binding; phosphate binding; protein binding; signal transducer activity; transcription factor activity