Recombinant Human SRSF10 Protein (1-183 aa), His-SUMO-tagged

• Cat.No.: SRSF10-990H
• Product Overview: Recombinant Human SRSF10 Protein (1-183 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length of Isoform 3.

Specification

• Description: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Ses to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
• Source: E. coli
• Species: Human
• Tag: His&SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 38.2 kDa
• Protein length: 1-183 aa
• AA Sequence: MSRYLRPPNTSLFVRNVADDTRSED LRREFGRYGPIVDVYVPLDFYTRRP RGFAYVQFEDVRDAEDALHNLDRKW ICGRQIEIQFAQGDRKTPNQMKAKE GRNVYSSSRYDDYDRYRRSRSRSYE RRRSRSRSFDYNYRRSYSPRNSRPT GRPRRSRSHSDNDRPNCSWNTQYSS AYYTSRKI
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: SRSF10 serine/arginine-rich splicing factor 10 [ Homo sapiens ]
• Official Symbol: SRSF10
• Synonyms: SRSF10; NSSR; SFRS13; SRp38; SRrp40; TASR1; TASR2; TASR; FUSIP1; FUSIP2; SFRS13A; FLJ30749; FLJ43846; DKFZp686H0644
• Gene ID: 10772
• mRNA Refseq: NM_001191005
• Protein Refseq: NP_001177934
• MIM: 605221
• UniProt ID: O75494

Reviews

05/25/2022

the SRSF10 Protein's applicability in protein electron microscopy structure analysis is remarkable.

02/09/2019

This protein has consistently demonstrated outstanding results, making it an indispensable tool in my research endeavors.

06/03/2017

In WB experiments, the SRSF10 Protein consistently delivers exceptional performance.

Q&As

What are the implications of SRSF10 protein in cardiovascular diseases?

SRSF10 protein has been linked to alternative splicing events in genes associated with cardiovascular diseases, indicating its potential relevance in this area.

What tools are used to study the clinical application of SRSF10 protein?

Techniques such as RNA sequencing, CRISPR/Cas9 gene editing, and antibody-based assays are used to study the role of SRSF10 protein in clinical applications.

How is the expression of SRSF10 protein regulated in cells?

The expression of SRSF10 protein is regulated by various mechanisms, including transcriptional control, post-transcriptional modifications, and protein stability.

How does SRSF10 protein impact RNA splicing?

SRSF10 protein modulates alternative splicing by binding to specific RNA sequences and influencing the inclusion or exclusion of particular exons in mRNA transcripts.

Can SRSF10 protein be targeted for personalized medicine?

Understanding the role of SRSF10 protein in specific disease contexts may lead to the development of personalized therapeutic approaches targeting this protein.