Recombinant Human SPTAN1, MYC/DDK-tagged

• Cat.No.: SPTAN1-479H
• Product Overview: Recombinant Human SPTAN1, transcript variant 1, fussed with MYC/DDK tag at C-terminal was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 284.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SPTAN1 spectrin, alpha, non-erythrocytic 1 [ Homo sapiens ]
• Official Symbol: SPTAN1
• Synonyms: NEAS; EIEE5; SPTA2; spectrin alpha chain, non-erythrocytic 1; alpha-II spectrin; alpha-fodrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit
• Gene ID: 6709
• mRNA Refseq: NM_001130438
• Protein Refseq: NP_001123910
• MIM: 182810
• UniProt ID: Q13813
• Chromosome Location: 9q34.11
• Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Axon guidance, organism-specific biosystem
• Function: actin binding; calcium ion binding; protein binding