Recombinant Human SPTAN1, His-tagged

Description :	Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
Source :	E. coli
Species :	Human
Tag :	His
Molecular Mass :	15.2kDa
Purity :	> 95%
Applications :	SDS-PAGE, Western Blot, ELISA, Immunoprecipitation
Usage :	For Research Use Only
Storage :	Can be stored at 4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Protein length :	289-408 a.a.

Gene Name	SPTAN1 spectrin, alpha, non-erythrocytic 1 [ Homo sapiens ]
Official Symbol	SPTAN1
Synonyms	NEAS; EIEE5; SPTA2; spectrin alpha chain, non-erythrocytic 1; alpha-II spectrin; alpha-fodrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit
Gene ID	670
mRNA Refseq	NM_001130438
Protein Refseq	NP_001123910
MIM	182810
UniProt ID	Q13813
Chromosome Location	9q34.11
Pathway	Caspase cascade in apoptosis, organism-specific biosystem; Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem; Developmental Biology, organism-specific biosystem
Function	protein binding; protein heterodimerization activity; spectrin binding