Recombinant Human SPG21 Protein, MYC/DDK-tagged

• Cat.No.: SPG21-2568H
• Product Overview: Recombinant Human SPG21 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 34.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) [ Homo sapiens ]
• Official Symbol: SPG21
• Synonyms: ACP33; BM-019; GL010; MAST
• Gene ID: 51324
• mRNA Refseq: NM_001127889
• Protein Refseq: NP_001121361
• MIM: 608181
• UniProt ID: Q9NZD8