Recombinant Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding), His-Fc-Tagged

• Cat.No.: TNFSF11-313H
• Product Overview: The monoclonal antibody to RANKL is a human IgG2 monoclonal antibody, have affinity and specificity with human RANKL (receptor activator of nuclear factor kappa-B ligand). 147 kDa Molecular weight, is genetically engineered mammalian (Chinese hamster ovary) cell production.

Specification

• Species: Human
• Source: Human
• Tag: Fc&His
• Description: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
• Form: Sterilized PBS, pH7.4
• Purity: > 95%
• Endotoxin: <1.0EU/10mg(LAL gel)
• Stability: 4μ: 6months. -20μ: 1 year, avoiding repeated freezing and thawing.
• Predicted N terminal: H-strand: EVQLLESGGG; L-strand: EIVLTQSPGT
• Molecular Mass: OPGL monoclonal antibody consists of 1326 Amino acids, Molecular Mass is 147KDa.
• Storage: 4μ for 6 months; -20 μ for 1 year, Avoiding repeated freezing and thawing.

Gene Information

• Gene Name: TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ]
• Official Symbol: TNFSF11
• Synonyms: TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factor ligand superfamily, member 11; OTTHUMP00000178585; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; CD254 antigen; Osteoprotegerin ligand
• Gene ID: 8600
• mRNA Refseq: NM_003701
• Protein Refseq: NP_003692
• MIM: 602642
• UniProt ID: O14788
• Chromosome Location: 13q14
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity; protein binding; receptor activity; tumor necrosis factor receptor binding