Recombinant Human SOX2, His-tagged

• Cat.No.: SOX2-667H
• Product Overview: Recombinant Human SOX2 is fused to an 8 amino acid His-Tag at C-terminus and purified by standard chromatography.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-200 a.a.
• Description: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
• Molecular Mass: 23.1kDa
• Physical Appearance: Sterile filtered colorless solution.
• Formulation: The SOX2 solution contains 20mM Tris-HCl pH-8, 2mM DTT, 0.2M NaCl & 40% glycerol.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Amino acid sequence: MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY LEHHHHHH.
• Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
• OfficialSymbol: SOX2
• Publications:
  Enzyme-immobilized 3D silver nanoparticle/graphene aerogel composites towards biosensors (2022)

Gene Information

• Gene Name: SOX2 SRY (sex determining region Y)-box 2 [ Homo sapiens ]
• Synonyms: SOX2; SRY (sex determining region Y)-box 2; ANOP3; MCOPS3; MGC2413; Transcription factor SOX-2; SRY-related HMG-box gene 2; transcription factor SOX2; sex-determining region Y-box 2
• Gene ID: 6657
• mRNA Refseq: NM_003106
• Protein Refseq: NP_003097
• MIM: 184429
• UniProt ID: P48431
• Chromosome Location: 3q26.3-q27
• Pathway: SIDS Susceptibility Pathways; Wnt Signaling Pathway and Pluripotency
• Function: DNA binding; chromatin binding; protein binding; sequence-specific DNA binding; transcription regulatory region DNA binding