Recombinant Human sodium voltage-gated channel alpha subunit 5 Protein, His tagged

• Cat.No.: SCN5A-13H
• Product Overview: Purified recombinant protein of Human sodium channel, voltage-gated, type V, alpha subunit (SCN5A), transcript variant 1, 450Ile-650Val, with N-terminal His tag, expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 450-650aa
• Description: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
• Tag: N-His
• Molecular Mass: 23.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Concentration: > 0.05 μg/μL as determined by microplate BCA method

Gene Information

• Gene Name: SCN5A sodium voltage-gated channel alpha subunit 5 [ Homo sapiens (human) ]
• Official Symbol: SCN5A
• Synonyms: SCN5A; sodium channel, voltage-gated, type V, alpha subunit; CMD1E, sodium channel, voltage gated, type V, alpha (long QT syndrome 3); sodium channel protein type 5 subunit alpha; CDCD2; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; long QT syndrome 3; LQT3; Nav1.5; PFHB1; SSS1; voltage-gated sodium channel subunit alpha Nav1.5; sodium channel protein cardiac muscle subunit alpha; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; VF1; CMD1E
• Gene ID: 6331
• mRNA Refseq: NM_198056
• Protein Refseq: NP_932173
• MIM: 600163
• UniProt ID: Q14524