Recombinant Human SMYD1, FLAG-tagged

• Cat.No.: Smyd1-73H
• Product Overview: Recombinant Human Smyd1 (accession number NP_938015.1) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 58.3 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Flag
• Description: SET and MYND domain-containing protein 1 (Smyd1) is a member of the Smyd family of histone methyltransferases that possesses H3K4 methyltransferase activity. It has also been shown to act as a transcriptional repressor. Studies suggest that Smyd1 may play a critical role in cardiomyocyte differentiation and cardiac morphogenesis and that it also may have a function in skeletal muscle development.
• Form: 20 mM Tris-HCl pH 7.4, 150 mM NaCl and 20% glycerol.
• Bio-activity: Not known. May methylate non-histone substrates.
• Applications: Enzyme kinetics, inhibitor screening, and selectivity profiling.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.4 mg/ml

Gene Information

• Gene Name: SMYD1 SET and MYND domain containing 1 [ Homo sapiens ]
• Official Symbol: Smyd1
• Synonyms: SMYD1; SET and MYND domain containing 1; SET and MYND domain-containing protein 1; BOP; KMT3D; ZMYND22; CD8 beta opposite; zinc finger, MYND domain containing 18; ZMYND18
• Gene ID: 150572
• mRNA Refseq: NM_198274
• Protein Refseq: NP_938015
• MIM: 606846
• UniProt ID: Q8NB12
• Chromosome Location: 2p11.1
• Pathway: Heart Development, organism-specific biosystem
• Function: DNA binding; metal ion binding; transcription corepressor activity; zinc ion binding