Description :	The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010].
Source :	HEK293
Species :	Human
Tag :	Myc&DDK
Form :	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass :	65 kDa
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration :	>50 ug/mL as determined by microplate BCA method

Gene Name	SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal [ Homo sapiens ]
Official Symbol	SMPD1
Synonyms	ASM; ASMASE; NPD
Gene ID	6609
mRNA Refseq	NM_000543
Protein Refseq	NP_000534
MIM	607608
UniProt ID	P17405