Recombinant Human SMAD5

• Cat.No.: SMAD5-31194TH
• Product Overview: Recombinant full length human SMAD5 with N-terminal proprietary tag; amino acids 1-465, 82kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-465 a.a.
• Description: The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.
• Tissue specificity: Ubiquitous.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the dwarfin/SMAD family.Contains 1 MH1 (MAD homology 1) domain.Contains 1 MH2 (MAD homology 2) domain.
• Full Length: Full L.

Gene Information

• Gene Name: SMAD5 SMAD family member 5 [ Homo sapiens ]
• Official Symbol: SMAD5
• Synonyms: SMAD5; SMAD family member 5; MAD, mothers against decapentaplegic homolog 5 (Drosophila) , MADH5, SMAD, mothers against DPP homolog 5 (Drosophila); mothers against decapentaplegic homolog 5; Dwfc; JV5 1
• Gene ID: 4090
• mRNA Refseq: NM_001001419
• Protein Refseq: NP_001001419
• MIM: 603110
• Uniprot ID: Q99717
• Chromosome Location: 5q31
• Pathway: ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Id Signaling Pathway, organism-specific biosystem; Signal Transduction, organism-specific biosystem
• Function: protein binding; receptor signaling protein activity; sequence-specific DNA binding transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding