Recombinant Human SLC7A5 Protein (A2-T507), 8×His-MBP, Flag tagged

• Cat.No.: SLC7A5-1256H
• Product Overview: Recombinant Human 8His-MBP-TEV-(GG)-SLC7A5(A2-T507)-Flag Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag&His&MBP
• Protein Length: A2-T507
• Description: The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier. May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier. Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 70%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Formulation:
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 [ Homo sapiens (human) ]
• Official Symbol: SLC7A5
• Synonyms: SLC7A5; solute carrier family 7 (amino acid transporter light chain, L system), member 5; large neutral amino acids transporter small subunit 1; CD98; D16S469E; E16; LAT1; MPE16; 4F2 LC; 4F2 light chain; CD98 light chain; integral membrane protein E16; L-type amino acid transporter 1; solute carrier family 7 member 5; large neutral amino acids transporter 1; y+ system cationic amino acid transporter; sodium-independent neutral amino acid transporter LAT1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; 4F2LC; hLAT1
• Gene ID: 8140
• mRNA Refseq: NM_003486
• Protein Refseq: NP_003477
• MIM: 600182
• UniProt ID: Q01650