Recombinant Human SLC2A1 protein, His&Myc-tagged

• Cat.No.: SLC2A1-3499H
• Product Overview: Recombinant Human SLC2A1 protein(P11166)(207-271aa), fused to N-terminal His tag and C-terminal Myc tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His&Myc
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 15.2 kDa
• Protein length: 207-271aa
• AA Sequence: CPESPRFLLINRNEENRAKSVLKKL RGTADVTHDLQEMKEESRQMMREKK VTILELFRSPAYRQP
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 [ Homo sapiens ]
• Official Symbol: SLC2A1
• Synonyms: SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1; GLUT, GLUT1; solute carrier family 2, facilitated glucose transporter member 1; DYT18; GLUT-1; hepG2 glucose transporter; glucose transporter type 1, erythrocyte/brain; PED; GLUT; DYT17; GLUT1; GLUT1DS; MGC141895; MGC141896
• Gene ID: 6513
• mRNA Refseq: NM_006516
• Protein Refseq: NP_006507
• MIM: 138140
• UniProt ID: P11166

Reviews

07/10/2021

Quality product, great results.

09/14/2020

Fast and efficient service.

02/13/2018

Excellent for immunofluorescence.

Q&As

What is the main function of SLC2A1 in cellular glucose transport?

SLC2A1 facilitates the passive transport of glucose across cell membranes, especially in conditions of low glucose concentration.

What specific substrates can SLC2A1 transport in addition to glucose?

Besides glucose, SLC2A1 can also transport other hexoses such as galactose.

How is SLC2A1 expression regulated under varying glucose conditions?

SLC2A1 expression is upregulated in response to low glucose availability to ensure sufficient glucose uptake.

What potential therapeutic interventions could target SLC2A1?

Therapeutic interventions could involve managing glucose levels and ketogenic diets to bypass the glucose transport defect in conditions like GLUT1 deficiency syndrome.

In which tissues is SLC2A1 predominantly expressed?

It is ubiquitously expressed but is particularly prevalent in erythrocytes and the endothelial cells of the blood-brain barrier.

What happens when there are mutations or dysregulations in SLC2A1?

Mutations or dysregulations in SLC2A1 can lead to glucose transport deficiencies, affecting energy supply to cells.

Has SLC2A1 been linked to any specific diseases or conditions?

Mutations in SLC2A1 are associated with GLUT1 deficiency syndrome, which can result in epilepsy, developmental delay, and movement disorders.