Recombinant Human SIGLEC15 protein, His-Avi-tagged

• Cat.No.: SIGLEC15-170H
• Product Overview: Human Siglec-15 is expressed from HEK293 with a His tag and Avi tag at the C-terminal. It contains Phe20-Thr263.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: It contains Phe20-Thr263.
• Description: Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates..
• Form: Supplied as 0.22um filtered solution in 20mM NaAc-HAc(pH 5.0) .
• Molecular Mass: The protein has a predicted MW of 29.5 kDa.Due to glycosylation, the protein migrates to 30- 38KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: SIGLEC15 sialic acid binding Ig like lectin 15 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC15
• Synonyms: CD33 antigen-like 3 SIGLEC-15; CD33 molecule-like 3; CD33L3; HsT1361; sialic acid binding Ig-like lectin 15; sialic acid-binding Ig-like lectin 15; Siglec15; Siglec-15
• Gene ID: 284266
• mRNA Refseq: NM_213602.3
• Protein Refseq: NP_998767.1
• MIM: 618105
• UniProt ID: Q6ZMC9