Recombinant Human SH2D1A, His-tagged

• Cat.No.: SH2D1A-31018TH
• Product Overview: Recombinant full-length human SH2D1A/SAP , with N termianl His tag, 148aa, 16.3kDa inclusive of tag.

Specification

• Description: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein length: 128 amino acids
• Conjugation: HIS
• Molecular Weight: 16.300kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP

Gene Information

• Gene Name: SH2D1A SH2 domain containing 1A [ Homo sapiens ]
• Official Symbol: SH2D1A
• Synonyms: SH2D1A; SH2 domain containing 1A; IMD5, lymphoproliferative syndrome , LYP, SH2 domain protein 1A; SH2 domain-containing protein 1A; DSHP; Duncans disease; EBVS; MTCP1; SAP; XLP; XLPD
• Gene ID: 4068
• mRNA Refseq: NM_002351
• Protein Refseq: NP_002342
• MIM: 300490
• Uniprot ID: O60880
• Chromosome Location: Xq25
• Pathway: Direct p53 effectors, organism-specific biosystem; Measles, organism-specific biosystem; Measles, conserved biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem
• Function: SH3/SH2 adaptor activity