Recombinant Human SGSH, MYC/DDK-tagged

Cat.No. : SGSH-279H
Product Overview : Recombinant Human SGSH fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.
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Species : Human
Source : HEK293
Tag : DDK&Myc
Description : This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.
Molecular Mass : 54.6 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Storagebuffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Concentration : >50 ug/mL as determined by microplate BCA method
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Storage : Store at -800C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
OfficialSymbol : SGSH
Gene Name SGSH N-sulfoglucosamine sulfohydrolase [ Homo sapiens ]
Synonyms SGSH; N-sulfoglucosamine sulfohydrolase; HSS; MPS3A; mucopolysaccharidosis type IIIA; SFMD; sulfamidase; heparan sulfate sulfatase; sulfoglucosamine sulfamidase; N-sulphoglucosamine sulphohydrolase; EC 3.10.1.1; Sulfoglucosamine sulfamidase; Sulphamidase
Gene ID 6448
mRNA Refseq NM_000199
Protein Refseq NP_000190
MIM 605270
UniProt ID P51688
Chromosome Location 17q25.3
Pathway Glycosaminoglycan degradation; Heparan sulfate degradation; Lysosome; MPS I - Hurler syndrome
Function N-sulfoglucosamine sulfohydrolase activity; catalytic activity; metal ion binding; sulfuric ester hydrolase activity

Not For Human Consumption!

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