Recombinant Human SGCB, His-tagged

• Cat.No.: SGCB-75H
• Product Overview: Recombinant human SGCB protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: SGCB also known as beta-sarcoglycan, is a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.
• Source: E.coli
• Species: Human
• Tag: His
• Form: Liquid, In 20mM Tris-HCl buffer(pH8.0) containing 10% glycerol
• Molecular Mass: 27.8kDa (255aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSWAVIRIG PNGCDSMEFH ESGLLRFKQV SDMGVIHPLY KSTVGGRRNE NLVITGNNQP IVFQQGTTKL SVENNKTSIT SDIGMQFFDP RTQNILFSTD YETHEFHLPS GVKSLNVQKA STERITSNAT SDLNIKVDGR AIVRGNEGVF IMGKTIEFHM GGNMELKAEN SIILNGSVMV STTRLPSSSS GDQLGSGDWV RYKLCMCADG TLFKVQVTSQ NMGCQISDNP CGNTH
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) [ Homo sapiens ]
• Official Symbol: SGCB
• Synonyms: SGCB; sarcoglycan, beta (43kDa dystrophin-associated glycoprotein); LGMD2E, sarcoglycan, beta (43kD dystrophin associated glycoprotein); beta-sarcoglycan; A3b; SGC; 43DAG; beta-SG; 43 kDa dystrophin-associated glycoprotein; limb girdle muscular dystrophy 2E (non-linked families); beta-sarcoglycan(43kD dystrophin-associated glycoprotein); LGMD2E
• Gene ID: 6443
• mRNA Refseq: NM_000232
• Protein Refseq: NP_000223
• MIM: 600900
• UniProt ID: Q16585
• Chromosome Location: 4q12
• Pathway: Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Viral myocarditis, organism-specific biosystem