Recombinant Human SERPINE2 protein, His-tagged

• Cat.No.: SERPINE2-187H
• Product Overview: Recombinant Human SERPINE2 (Ser20-Pro397) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: Ser20-Pro397
• Description: SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1). SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). PAI-1/GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1/PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.
• Predicted N Terminal: Ser20
• Form: Lyophilized from 0.22 μm filtered solution in 20 mM Sodium Acetate, 100 mM NaCl, pH6.5, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 42.7 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >92% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: SERPINE2
• Official Symbol: SERPINE2
• Synonyms: SERPINE2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; PI7, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; glia-derived nexin; GDN; glial derived nexin 1; nexin; PN1; PNI; serpin E2; protease nexin I; peptidase inhibitor 7; glial-derived neurite promoting factor; PI7; PI-7; PN-1; DKFZp686A13110
• Gene ID: 5270
• mRNA Refseq: NM_001136528
• Protein Refseq: NP_001130000
• MIM: 177010
• UniProt ID: P07093