Recombinant Human Serine/Threonine Kinase 38, GST-tagged

• Cat.No.: STK38-1106H
• Product Overview: Full-length recombinant human STK38 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: STK38 is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. STK38 acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleared by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 81 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
• Specific Activity: 4 nmol/min/mg
• Purity: > 70 %
• Concentration: 0.1 ug/ul
• Sequences: Full-length
• Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: STK38 serine/threonine kinase 38 [ Homo sapiens ]
• Official Symbol: STK38
• Synonyms: STK38; serine/threonine kinase 38; NDR; NDR1; Nuclear Dbf2-related kinase 1; NDR1 protein kinase; serine/threonine-protein kinase 38; serine threonine protein kinase; nuclear Dbf2-related 1; EC 2.7.11.1
• Gene ID: 11329
• mRNA Refseq: NM_007271
• Protein Refseq: NP_009202
• MIM: 606964
• UniProt ID: Q15208
• Chromosome Location: 6p21
• Function: ATP binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity