Recombinant Human Serine/Threonine Kinase 33, GST-tagged, Active

• Cat.No.: STK33-438H
• Product Overview: Recombinant full-length human STK33 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 94 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: STK33 is a distant member of the CAMK group of serine/threonine kinases but it lacks the calcium/calmodulin-binding domain and the C-terminal regulatory tail. STK33 is highly expressed in testis, lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. STK33 is essential for abnormal cell growth in human cell lines expressing oncogenic mutations in KRAS, but not in human cancer cell lines expressing wildtype KRAS. STK33 is required for survival and proliferation of mutant KRAS-dependent cancer cells, in which it suppresses the S6K1-BAD proapoptotic signaling pathway.
• Sequence: Full length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: STK33 serine/threonine kinase 33 [ Homo sapiens ]
• Synonyms: STK33; serine/threonine kinase 33; OTTHUMP00000178935; OTTHUMP00000208016; EC 2.7.11.1
• Gene ID: 65975
• mRNA Refseq: NM_030906
• Protein Refseq: NP_112168
• MIM: 607670
• UniProt ID: Q9BYT3
• Chromosome Location: 11p15.3
• Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity