Recombinant Human SEPTIN5 Protein (Ser77-Ser323), N-His tagged

• Cat.No.: SEPTIN5-5446H
• Product Overview: Recombinant human SEPTIN5 (Ser77-Ser323) fused with the N-His tag was expressed in E. coli.

Specification

• Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 30.95 kDa
• Protein length: Ser77-Ser323
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02 % NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SEPTIN5 septin 5 [ Homo sapiens (human) ]
• Official Symbol: SEPTIN5
• Synonyms: SEPTIN5; septin 5; H5; SEPT5; CDCREL; PNUTL1; CDCREL1; CDCREL-1; Septin-5; HCDCREL-1; septin-5; cell division control related protein 1; peanut-like 1; platelet glycoprotein Ib beta chain; EC 3.1.5.1
• Gene ID: 5413
• mRNA Refseq: NM_002688
• Protein Refseq: NP_002679
• MIM: 602724
• UniProt ID: Q99719